Non-NMDA receptor-mediated neurotoxicity in cortical culture
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چکیده
منابع مشابه
Non-NMDA receptor-mediated neurotoxicity in cortical culture.
The neurotoxicity of 3 non-NMDA glutamate receptor agonists--kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA), and quisqualate--was investigated quantitatively in dissociated murine cortical cultures. Five minute exposure to 500 microM kainate, but not AMPA, produced widespread acute neuronal swelling. Kainate-induced swelling was resistant to 2-amino-5-phosphonovalerate (A...
متن کاملThe effect of ketamine on NMDA receptor-mediated LTP depends on ketamine effects on non-NMDA-mediated synaptic transmission in CA1 area of rat hippocampal slices
It has been reported that ketamine as an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist has also non-NMDA receptor antagonist properties. We recently found that ketamine (20 ?M) affected differently induction of NMDA receptor-mediated long-term potentiation (LTP) when administered 30 min prior to tetanic Primed-Bursts (PBs) stimulation. On the other hand, ketamine also influenced...
متن کاملThe effect of ketamine on NMDA receptor-mediated LTP depends on ketamine effects on non-NMDA-mediated synaptic transmission in CA1 area of rat hippocampal slices
It has been reported that ketamine as an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist has also non-NMDA receptor antagonist properties. We recently found that ketamine (20 ?M) affected differently induction of NMDA receptor-mediated long-term potentiation (LTP) when administered 30 min prior to tetanic Primed-Bursts (PBs) stimulation. On the other hand, ketamine also influenced...
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The central neurotoxicity of the excitatory amino acid neurotransmitter glutamate has been postulated to participate in the pathogenesis of the neuronal cell loss associated with several neurological disease states, but the complexity of the intact nervous system has impeded detailed analysis of the phenomenon. In the present study, glutamate neurotoxicity was studied with novel precision in di...
متن کاملPharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
The antagonist pharmacology of glutamate neurotoxicity was quantitatively examined in murine cortical cell cultures. Addition of 1-3 mM DL-2-amino-5-phosphonovalerate (APV), or its active isomer D-APV, acutely to the exposure solution selectively blocked the neuroexcitation and neuronal cell selectively blocked the neuroexcitation and neuronal cell loss produced by N-methyl-D-aspartate (NMDA), ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1990
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.10-02-00693.1990